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METABOLIC ENGINEERING FOR ENHANCED SUCCINIC ACID BIOSYNTHESIS

United States Patent Application

20170306363
A1
View the Complete Application at the US Patent & Trademark Office
National Renewable Energy Laboratory - Visit the NREL Technology Transfer Website
Presented herein are biocatalysts and methods for the production of succinic acid from carbon sources. The biocatalysts include microbial cells that have been engineered to overexpress exogenously added genes that encode enzymes active in the reductive branch of the tricarboxylic acid (TCA) cycle.
GUARNIERI, Michael T. (Denver, CO), CHOU, Yat-Chen (Lakewood, CO), BECKHAM, Gregg Tyler (Golden, CO), SALVACH A RODR GUEZ, Davinia (Golden, CO)
15/ 496,944
April 25, 2017
CONTRACTUAL ORIGIN [0002] The United States Government has rights in this invention under Contract No. DE-AC36-08GO28308 between the United States Department of Energy and Alliance for Sustainable Energy, LLC, the Manager and Operator of the National Renewable Energy Laboratory.