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ENGINEERED FGF COMPOSITIONS AND METHODS OF USE THEREOF

United States Patent Application

20170281790
A1
View the Complete Application at the US Patent & Trademark Office
The present invention relates to the development of stable mutants of FGF-1 and FGF-2. In particular, it relates to novel engineered FGF-1 and FGF-2 polypeptides as well as polynucleotides, DNA constructs, and vectors encoding such polypeptides. In another aspect, pharmaceutical compositions and hydrogels including the disclosed polypeptides, polynucleotides, DNA constructs, and vectors are provided. In a still further aspect, methods of treating conditions using the compositions disclosed herein are provided.
Thallapuranam, Suresh Kumar (Fayetteville, AR), Zaharoff, David A. (Morrisville, NC), Jayanthi, Srinivas (Fayetteville, AR), Koppolu, Bhanuprasanth (Cary, NC), Kerr, Rebecca (Fayetteville, AR), Balachandran, Kartik (Fayetteville, AR), McNabb, David S. (Fayetteville, AR)
THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSA (Little Rock AR)
15/ 474,268
March 30, 2017
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH [0002] This invention was made with government support under grant numbers NCRR COBRE Grant 1 P20 RR15569 and P30 GM103450 awarded by the National Institutes of Health, Grant DE-FG02-01ER15161 awarded by the Department of Energy, and Grant IOS0843397 9TO awarded by the National Science Foundation. The United States Government has certain rights in the invention.