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ENZYME SCAFFOLDS AND METHODS OF USE

United States Patent Application

20170275653
A1
View the Complete Application at the US Patent & Trademark Office
National Renewable Energy Laboratory - Visit the NREL Technology Transfer Website
Polypeptide scaffolds comprising enzymatic proteins are provided. The enzymatic polypeptide scaffolds comprise heterologous enzymes to form a heterologous metabolic pathway, and can be targeted to a substrate through a surface anchoring domain. The enzymatic polypeptide scaffolds leverage the high specificity and affinity protein/protein interaction between the cohesins and dockerins of microorganismal cellulosomes to form custom enzymatic arrays.
BOMBLE, Yannick J. (Arvada, CO), HIMMEL, Michael E. (Littleton, CO), LINGER, Jeffrey (Denver, CO), BRUNECKY, Roman (Arvada, CO), AIKENS, John (La Grange, IL)
15/ 467,340
March 23, 2017
CONTRACTUAL ORIGIN [0002] United States Government has rights in this disclosure under Contract No. DE-AC36-08GO28308 between the United States Department of Energy and Alliance for Sustainable Energy, LLC, the Manager and Operator of the National Renewable Energy Laboratory.