A nanoparticle radionuclide delivery system includes a radionuclide core, a non-radioactive inorganic layer encasing the radionuclide core to form an encased radionuclide, at least one coupling moiety, and at least one vector biomolecule specific to a target tissue. The coupling moiety includes a first reactive group bound to the non-radioactive layer of the encased radionuclide and a second reactive group bound to the vector biomolecule. The vector biomolecule is a monoclonal antibody or fragment thereof, or a peptide having an affinity for the target tissue.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT
 The United States Government has rights in this invention pursuant to Contract No. DE-AC05-000R22725 between the United States Department of Energy and UT-Battelle, LLC.