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Radionuclide nanoparticles encased by inorganic shell having vector biomolecules attached thereto

United States Patent Application

20070009436
A1
View the Complete Application at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
A nanoparticle radionuclide delivery system includes a radionuclide core, a non-radioactive inorganic layer encasing the radionuclide core to form an encased radionuclide, at least one coupling moiety, and at least one vector biomolecule specific to a target tissue. The coupling moiety includes a first reactive group bound to the non-radioactive layer of the encased radionuclide and a second reactive group bound to the vector biomolecule. The vector biomolecule is a monoclonal antibody or fragment thereof, or a peptide having an affinity for the target tissue.
Rondinone, Adam J. (Knoxville, TN), Dai, Sheng (Knoxville, TN), Luo, Huimin (Knoxville, TN), Brown, Suree S. (Knoxville, TN)
11/ 177,039
July 8, 2005
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0001] The United States Government has rights in this invention pursuant to Contract No. DE-AC05-000R22725 between the United States Department of Energy and UT-Battelle, LLC.