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Synthesis of labeled compounds

United States Patent Application

20070004929
A1
View the Complete Application at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
The present invention is directed to labeled compounds of the formula Ar-Z.sub.1-Q-Z.sub.2 where Ar is an aryl group is selected from the group consisting of 1-naphthyl, substituted 1-naphthyl, 2-naphthyl, substituted 2-naphthyl, and phenyl groups with the structure ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4 and R.sub.5 are each independently selected from the group consisting of hydrogen, a C.sub.1-C.sub.4 lower alkyl, a halogen, a phenyl, an alkoxy group and an amino group from the group consisting of NH.sub.2, NHR and NRR' where R and R' are each a C.sub.1-C.sub.4 lower alkyl, Q is selected from the group consisting of .sup.13CH.sub.2, .sup.13CDH and .sup.13CD.sub.2, and Z.sub.1 is selected from the group consisting of --S--, --S(.dbd.O)--, --S(.dbd.O).sub.2--, --Se--, --Se(.dbd.O)--, and --Se(.dbd.O).sub.2--, Z.sub.2 is selected from the group consisting of --Si(R.sub.6R.sub.7R.sub.8), --O(R.sub.9), --Se--Ar, --Se(.dbd.O)--Ar, --Se(.dbd.O).sub.2--Ar, --S--Ar, --S(.dbd.O)--Ar, and --S(.dbd.O).sub.2--Ar wherein R.sub.6, R.sub.7 and R.sub.8 are each independently selected from the group consisting of a C.sub.1-C.sub.4 lower alkyl, R.sub.9 is a C.sub.1-C.sub.4 lower alkyl or an R.sub.10--Ar group where R.sub.10 is a C.sub.1-C.sub.4 alkylene group.
Martinez, Rodolfo A. (Santa Fe, NM), Schmidt, Jurgen G. (Los Alamos, NM), Alvarez, Marc A. (Santa Fe, NM), Silks, Louis A. (Los Alamos, NM)
11/ 172,126
June 29, 2005
STATEMENT REGARDING FEDERAL RIGHTS [0001] This invention was made with government support under Contract No. W-7405-ENG-36 awarded by the U.S. Department of Energy. The government has certain rights in the invention.