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Production of Acrylate in Cells

United States Patent Application

20170218409
A1
View the Complete Application at the US Patent & Trademark Office
A method of producing acrylate in vivo in a genetically modified bacteria cell is provided including providing a cell with a first one or more nucleic acids encoding a pathway resulting in the production of 3-hydroxypropionate, providing the cell with a second one or more nucleic acids encoding a truncated pcs enzyme lacking a domain converting acrylyl-CoA to propionyl-CoA, providing the cell with a third one or more nucleic acids encoding acrylyl-CoA hydrolase, wherein the cell expresses the first, second and third one or more nucleic acids and produces acrylate.
Rogers, Jameson K. (Boston, MA), Church, George M. (Brookline, MA)
15/ 421,495
February 1, 2017
STATEMENT OF GOVERNMENT INTERESTS [0002] This invention was made with government support under DE-FG02-02ER63445 awarded by the U.S. Department of Energy. The government has certain rights in the invention.