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CHARACTERIZATION OF TRACE CRYSTALLINITY BY SECOND HARMONIC GENERATION MICROSCOPY

United States Patent Application

20170212053
A1
View the Complete Application at the US Patent & Trademark Office
A method for quantifying crystallinity within a sample using second harmonic generation microscopy is described herein. In one aspect, a method for reducing the timeframe for accelerated stability testing of amorphous solid dispersions of active pharmaceutical ingredients though identifying regions of interest to quantify crystallinity and composition is presented herein.
Simpson, Garth Jason (West Lafayette, IN), Schmitt, Paul David (Zionsville, IN)
Purdue Research Foundation (West Lafayette IN)
15/ 514,893
September 28, 2015
STATEMENT OF GOVERNMENT INTEREST [0002] This invention was made with government support under FD-U-004275 awarded by the Food and Drug Administration and DE-SC0000997 awarded by the U.S. Department of Energy. The government has certain rights in the invention.