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COMPOSITIONS AND METHODS FOR DETECTION OF SMALL MOLECULES

United States Patent Application

20170198363
A1
View the Complete Application at the US Patent & Trademark Office
Compositions and methods are provided for the detection of small molecules in a cell using biosensor molecules comprising conditionally active ligand binding domains. Compositions for conditionally activating transcription based on the presence of a small molecules in a cell are further provided, together with methods of designing, producing, and expressing biosensor molecules in cells.
MEDFORD, JUNE (WELLINGTON, CO), ANTUNES, MAURICIO (FORT COLLINS, CO), MOREY, KEVIN (WINDSOR, CO), JESTER, BENJAMIN (SEATTLE, WA), TINBERG, CHRISTINE (SEATTLE, WA), FIELDS, STANLEY (SEATTLE, WA), BAKER, DAVID (SEATTLE, WA), BICK, MATTHEW (SEATTLE, WA)
15/ 392,962
December 28, 2016
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH [0002] This invention was made with partial government support by funding from the U.S. Department of Defense/Defense Threat Reduction Agency under grant number numbers W911NF-09-1-0526 and HDTRA1-13-1-0054; funding from the National Institutes of Health under grant number P41 GM103533; funding from the Department of Energy under grant number DE-FG02-02ER63445; funding from the National Science Foundation (NSF)/Synthetic Biology Engineering Research Center (SynBERC) under grant numbers MCB-134189 and EEC-0540879; and funding from the NSF under Graduate Research Fellowship grant number DGE1144152. The Government has certain rights in the invention.