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SYNTHESIZING PET TRACERS USING [F-18]SULFONYL FLUORIDE AS A SOURCE OF [F-18]FLUORIDE

United States Patent Application

20170197912
A1
View the Complete Application at the US Patent & Trademark Office
The present disclosure relates to the methods for the preparation of reactive [F-18]fluoride in a form of [F-18]sulfonyl fluoride suitable for efficient radiolabeling without an azeotropic evaporation step by the use of anion exchange resin and sulfonyl chloride, and its applications in the manufacturing of PET radiopharmaceuticals.
Zhou, Dong (St. Louis, MO), Chu, Wenhua (St. Louis, MO)
Washington University (St. Louis MO)
15/ 403,954
January 11, 2017
GOVERNMENTAL RIGHTS [0002] This invention was made with government support under DESC0008432 awarded by the Department of Energy and CA025836 awarded by the National Institutes of Health. The government has certain rights in the invention.