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HYBRID POLYKETIDE SYNTHASES

United States Patent Application

20170015990
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin.
Fortman, Jeffrey L. (San Francisco, CA), Hagen, Andrew (Berkeley, CA), Katz, Leonard (Oakland, CA), Keasling, Jay D. (Berkeley, CA), Poust, Sean (Berkeley, CA), Zhang, Jingwei (San Francisco, CA), Zotchev, Sergey (Tondheim, NO)
15/ 144,727
May 2, 2016
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy and Award No. 0540879 awarded by the National Science Foundation. The government has certain rights in the invention