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SCALABLE ORGANOTYPIC MODELS OF TUMOR DORMANCY

United States Patent Application

20170114329
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Herein are described synthetic organotypic microvascular niches formed by self-assembly of stromal cells cultured endothelial cells seeded with cells of interest to model and determine dormancy state of these cells of interest in these tissues. These models demonstrated that endothelial-derived thrombospondin-1 induces sustained cancer cell quiescence. We further describe dormancy models, and identified active tumor-promoting, endothelial tip cell-derived factors. Our work reveals that stable microvasculature constitutes a `dormant niche,` whereas sprouting neovasculature sparks micrometastatic outgrowth.
Ghajar, Cyrus M. (Greenbrae, CA), Bissell, Mina J. (Berkeley, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
14/ 944,137
November 17, 2015
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The present invention was supported by Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy and by Grant Nos. CA126552 and CA143836 awarded by the National Institutes of Health. The government has certain rights to the invention.