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METHODS FOR PRODUCING MICROCOMPARTMENTS

United States Patent Application

20170107523
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
To produce a bacterial microcompartment shell, or a designed shell based on naturally occurring bacterial microcompartment shells in a new host organism, a synthetic operon is constructed that contains the desired shell protein genes and translation efficiency is controlled by host specific ribosomal binding sites. Proteins or other molecules can be encapsulated in the microcompartment shells by various methods described herein. The constructs can also be used to express self-assembling sheets comprised of shell proteins.
Kerfeld, Cheryl A. (Walnut Creek, CA), Lassila, Jonathan K. (South San Francisco, CA), Kinney, James N. (Clayton, CA), Sutter, Markus (Berkeley, CA), Wilson, Steven C. (Rohnert Park, CA)
15/ 367,089
December 1, 2016
STATEMENT OF GOVERNMENTAL SUPPORT [0003] This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy, under Contract No. DE-0000200 awarded by the Department of Energy ARPA-E, and under Grant Nos. MCB0851094 and MCB1160614 awarded by the National Science Foundation. The government has certain rights in the invention.