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METHOD FOR DESIGNING OVERALL STOICHIOMETRIC CONVERSIONS AND INTERVENING METABOLIC REACTIONS

United States Patent Application

20170116369
A1
View the Complete Application at the US Patent & Trademark Office
The present invention describes a two-step computational procedure that both identifies the optimum overall stoichiometry of conversion, along with alternate co-reactant (or co-product) combinations, of a feedstock substrate to a biochemical product, and selects for (non-)native reactions accessed from a universal database to identify at least one stoichiometry-balanced minimal metabolic network, in terms of number of reactions or sum of the flux in the network, that maximize carbon or energy efficiency while satisfying thermodynamic feasibility requirements. A representation of the overall stoichiometry of conversion and the minimal metabolic network as designed can be stored.
Chowdhury, Anupam (University Park, PA), Maranas, Costas D. (University Park, PA)
15/ 146,602
May 4, 2016
GRANT REFERENCE [0002] This invention was made with government support under Grant No. DE-SC0008091, awarded by the Department of Energy and under Grant No. EEC0813570, awarded by the National Science Foundation. The Government has certain rights in the invention.