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CONSTRUCTS AND SYSTEMS AND METHODS FOR ENGINEERING A CO2 FIXING PHOTORESPIRATORY BY-PASS PATHWAY

United States Patent Application

20170088850
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Methods and compositions to introduce a synthetic pathway based on the 3-hydroxypropionate bicycle into an organism such as the model cyanobacterium, Synechococcus elongatus sp. PCC 7942. The heterologously expressed pathway acts as a photorespiratory bypass as well as an additional carbon fixation cycle orthogonal to the endogenous Calvin-Benson cycle. We demonstrate the function of all six introduced enzymes, which not only has implications on increasing net-photosynthetic productivity, but also key enzymes in the pathway are involved in high-value products that are of biotechnological interest, such as 3-hydroxypropionate.
Kerfeld, Cheryl A. (Walnut Creek, CA), Shih, Patrick (Berkeley, CA), Zarzycki, Jan (East Lansing, MI), Niyogi, Krishna K. (Oakland, CA)
The Regents of the University of California (Oakland CA)
15/ 230,332
August 5, 2016
STATEMENT OF GOVERNMENTAL SUPPORT [0002] This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy, under Grant No. MCB0851054 awarded by the National Science Foundation. The government has certain rights in the invention.