Skip to Content
Find More Like This
Return to Search

BI-TERMINAL PEGYLATED INTEGRIN-BINDING PEPTIDES AND METHODS OF USE THEREOF

United States Patent Application

20170174723
A1
View the Complete Application at the US Patent & Trademark Office
The present invention provides bi-terminal PEGylated peptide conjugates that target an integrin such as .alpha..sub.v.beta..sub.6 integrin. In particular embodiments, the peptide conjugates of the present invention further comprise a biological agent such as an imaging agent or a therapeutic agent, e.g., covalently attached to one of the PEG moieties. The peptide conjugates of the present invention are particularly useful for imaging a tumor, organ, or tissue and for treating integrin-mediated diseases and disorders such as cancer, inflammatory diseases, autoimmune diseases, chronic fibrosis, chronic obstructive pulmonary disease (COPD), lung emphysema, and chronic wounding skin disease. Compositions and kits containing the peptide conjugates of the present invention find utility in a wide range of applications including, e.g., in vivo imaging and immunotherapy.
Hausner, Sven H. (Sacramento, CA), Sutcliffe, Julie L. (Sebastopol, CA)
The Regents of the University of California (Oakland CA)
15/ 292,564
October 13, 2016
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] This invention was made with Government support under Grant No. DE-SC0002061, awarded by the Department of Energy. The Government has certain rights in this invention.