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ANTIBIOTIC PROTOCELLS AND RELATED PHARMACEUTICAL FORMULATIONS AND METHODS OF TREATMENT

United States Patent Application

20170165375
A1
View the Complete Application at the US Patent & Trademark Office
Sandia National Laboratories - Visit the Intellectual Property Management and Licensing Website
The invention provides novel antibiotic protocells comprising mesoporous nanoparticles encapsulated within a lipid bi- or multilayer. The nanoparticles have pore sizes and surface chemistries that enable facile adsorption and intracellular presentation of antibiotics which are effective in the treatment of a wide variety of bacterial infections, including F. tularensis, B. pseudomallei and P. aeruginosa-related infections. Related pharmaceutical compositions and methods of treatment are also provided.
Ashley, Carlee Erin (Albuquerque, NM), Carnes, Eric C. (Albuquerque, NM), Wu, Terry (Albuquerque, NM), Felton, Linda A. (Albuquerque, NM), Sasaki, Darryl Y. (Livermore, CA)
14/ 781,817
April 2, 2014
STATEMENT REGARDING FEDERAL FUNDING [0002] This invention was developed under Contract DE-AC04-94AL85000 between Sandia Corporation and the U.S. Department of Energy. Accordingly, the United States has certain rights in this invention.