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United States Patent Application

View the Complete Application at the US Patent & Trademark Office
A particle usable as T.sub.1 and T.sub.2 contrast agents is provided. The particle is a gadolinium silicide (Gd.sub.5Si.sub.4) particle that is ferromagnetic at temperatures up to 290 K and is less than 2 .mu.m in diameter. An MRI contrast agent that includes a plurality of gadolinium silicide (Gd.sub.5Si.sub.4) particles that are less than 1 .mu.m in diameter is also provided. A method for creating gadolinium silicide (Gd.sub.5Si.sub.4) particles is also provided. The method includes the steps of providing a Gd.sub.5Si.sub.4 bulk alloy; grinding the Gd.sub.5Si.sub.4 bulk alloy into a powder; and milling the Gd.sub.5Si.sub.4 bulk alloy powder for a time of approximately 20 minutes or less.
Hadimani, Magundappa Ravi L. (Glen Allen, VA), Gupta, Shalabh (Ames, IA), Harstad, Shane (Rockford, MN), Pecharsky, Vitalij (Ames, IA), Jiles, David C. (Ames, IA)
Iowa State University Research Foundation, Inc. (Ames IA)
15/ 332,940
October 24, 2016
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] This invention was made in part with Government support under Grant No. DE-AC02-07CH11358 awarded by the Department of Energy. The Government has certain rights in this invention.