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De Novo Design of Allosteric Proteins

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Methods and compositions for making and isolating allosteric DNA binding proteins that bind to one or more allosteric effectors to induce a conformation change in the proteins are provided.
Raman, Srivatsan (Arlington, MA), Taylor, Noah D. (Boston, MA), Church, George M. (Brookline, MA)
15/ 120,228
February 20, 2015
STATEMENT OF GOVERNMENT INTERESTS [0002] This invention was made with government support under DE-FG02-02ER63445 awarded by the U.S. Department of Energy. The government has certain rights in this invention.