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BIS-POLYMER LIPID-PEPTIDE CONJUGATES AND NANOPARTICLES THEREOF

United States Patent Application

20170049901
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides bis-polymer lipid-peptide conjugates containing a hydrophobic block and headgroup containing a helical peptide and two polymer blocks. The conjugates can self-assemble to form helix bundle subunits, which in turn assemble to provide micellar nanocarriers for drug cargos and other agents. Particles containing the conjugates and methods for forming the particles are also disclosed.
Xu, Ting (Berkeley, CA), Dong, He (Albany, CA), Shu, Jessica (San Francisco, CA), Dube, Nikhil (Berkeley, CA)
14/ 490,336
September 18, 2014
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] This invention was made with Government support under Grant No. W91NF-09-1-0374, awarded by the Office of the Army of the U. S. Department of Defense, Grant No. DE-ACO2-05CH11231, awarded by the Office of Science, Office of Basic Energy Sciences, of the U.S. Department of Energy. The Government has certain rights in this invention.