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Useful halophilic, thermostable and ionic liquids tolerant cellulases

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for an isolated or recombinant polypeptide comprising an amino acid sequence having at least 70% identity with the amino acid sequence of a Halorhabdus utahensis cellulase, such as Hu-CBH1, wherein said amino acid sequence has a halophilic thermostable and/or thermophilic cellobiohydrolase (CBH) activity. In some embodiments, the polypeptide has a CBH activity that is resistant to up to about 20% of ionic liquids. The present invention also provides for compositions comprising and methods using the isolated or recombinant polypeptide.
Zhang, Tao (San Diego, CA), Datta, Supratim (Berkeley, CA), Simmons, Blake A. (San Francisco, CA), Rubin, Edward M. (Berkeley, CA)
The Regents of the University of California (Oakland CA), Sandia Corporation (Albuquerque NM)
15/ 164,813
May 25, 2016
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in the invention.