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SITE-SPECIFIC DYNAMIC NUCLEAR POLARIZATION NMR AGENTS

United States Patent Application

20170029377
A1
View the Complete Application at the US Patent & Trademark Office
Dynamic nuclear polarization (DNP) agents are provided for DNP nuclear magnetic resonance of analytes. The DNP agents can have the structure A-X-L-R, where A is none or an amphiphilic group; X is a coupling group capable of site-specific binding with the analyte or, when A is an amphiphilic group, capable of site-specific binding with the amphiphilic group; L is a bond or a linker group; and R is a poly-radical group. The poly-radical can be a di-radical, a tri-radical, a tetra-radical, or a combination thereof. Methods of NMR measurement of an analyte comprising an NMR-detectable nucleus are provided. The methods can include the steps of providing a frozen sample containing the analyte and a DNP agent; applying radiation having a frequency that excites electron spin transitions in the DNP agent at an intensity to polarize the NMR-detectable nucleus; and detecting a signal from nuclear spin transitions in the NMR-detectable nucleus.
Smirnov, Alexej I. (Raleigh, NC), Voynov, Maxim Anatolyevich (Raleigh, NC)
15/ 222,428
July 28, 2016
STATEMENT OF GOVERNMENT SUPPORT [0002] This invention was made with government support under Award Number DE-FG02-02ER15354 awarded by The Department of Energy. The government has certain rights in the invention.