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Using gene panels to predict tissue sensitivity to ionizing radiation

United States Patent Application

20060234272
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
A method of predicting sensitivity to radiation comprises selecting at least one of a first panel of genes associated with increased chromosomal damage and a second panel of genes associated with reduced chromosomal damage. The tissue is exposed to radiation. The RNA of the tissue is measured providing measured RNA of the first panel of genes associated with increased chromosomal damage and providing measured RNA of the second panel of genes associated with reduced chromosomal damage. Sensitivity to radiation is predicted using at least one of the measured RNA of the first panel of genes associated with increased chromosomal damage and the measured RNA of the second panel of genes associated with reduced chromosomal damage.
Wyrobek, Andrew J. (Walnut Creek, CA), Coleman, Matthew A. (Oakland, CA), Nelson, David O. (Oakland, CA)
The Regents of the University of California
11/ 390,584
March 27, 2006
[0002] The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.