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METHODS AND APPARATUS FOR PREPARING SPECIMENS FOR ELECTRON MICROSCOPY

United States Patent Application

20170004953
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
This disclosure provides systems, methods, and apparatus related to the preparation of electron microscopy specimens. In one aspect, a method includes providing an electron microscopy grid. An aqueous suspension including an electron microscopy sample is deposited on the electron microscopy grid. A portion of the aqueous suspension is removed from the electron microscopy grid. A volatile surfactant is contacted to the aqueous suspension. A thickness of aqueous suspension is allowed to decrease over a period of time. The aqueous suspension is then frozen.
Glaeser, Robert M. (Berkeley, CA), Han, Bong-Gyoon (Castro Valley, CA)
15/ 194,777
June 28, 2016
STATEMENT OF GOVERNMENT SUPPORT [0002] This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy and under Grant No. GM083039 from the National Institutes of Health. The government has certain rights in this invention.