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Ambient Infrared Laser Ablation Mass Spectrometry (AIRLAB-MS) with Plume Capture by Continuous Flow Solvent Probe

United States Patent Application

*** PATENT GRANTED ***
20170004959
9,805,921
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
A new experimental setup for spatially resolved ambient infrared laser ablation mass spectrometry (AIRLAB-MS) that uses an infrared microscope with an infinity-corrected reflective objective and a continuous flow solvent probe coupled to a Fourier transform ion cyclotron resonance mass spectrometer is described. The efficiency of material transfer from the sample to the electrospray ionization emitter was determined using glycerol/methanol droplets containing 1 mM nicotine and is .about.50%. This transfer efficiency is significantly higher than values reported for similar techniques.
O'Brien, Jeremy T. (Cambridge, MA), Williams, Evan R. (Oakland, CA), Holman, Hoi-Ying N. (Oakland, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
14/ 740,176
June 15, 2015
STATEMENT OF GOVERNMENTAL SUPPORT [0002] This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy and under Grant CHE-1306720 awarded by the National Science Foundation. The government has certain rights in the invention.