A relational database management system for automated random crystallization screening systems so as to provide facilitated data tracking, maintenance, and analysis. The system includes a database server module capable of storing data; an ARCS module having a crystallization screen design engine capable of generating random crystallization screens and associated crystallization experiments, and a data entry and query applications module capable of passing data between the database server module and a user. The database server module operates to correlate the data received from the ARCS module and the data entry and query applications module with sample data, to organize the data so as to systematically reveal, for example, conditions that do and do not lead to crystal growth.
 The United States Government has rights in this invention pursuant to Contract No. W-7405-ENG-48 between the United States Department of Energy and the University of California for the operation of Lawrence Livermore National Laboratory.