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ALPHA-V BETA-6 INTEGRIN-BINDING ANTIBODY FRAGMENTS

United States Patent Application

20160368993
A1
View the Complete Application at the US Patent & Trademark Office
The present invention provides isolated, engineered multivalent antibody fragments that specifically bind .alpha..sub.V.beta..sub.6 integrin. In particular embodiments, the antibody fragments of the present invention further comprise an imaging agent and/or a therapeutic agent. In some instances, the antibody fragments also include unnatural amino acids and/or inserted cysteine or thiol residues at the C-terminus of the scFv molecules of the fragments. The anti-.alpha..sub.V.beta..sub.6 integrin antibody fragments provided herein are particularly useful for imaging a tumor, organ or tissue and for treating an .alpha..sub.V.beta..sub.6 integrin-mediated disease or disorder. Compositions and kits containing the multivalent antibody fragments of the present invention are also described herein.
Sutcliffe, Julie L. (Davis, CA), WHITE, JASON BRADLEY (Davis, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
15/ 171,952
June 2, 2016
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] This invention was made with Government support under Grant Nos. DE-SC0002061 and DE-SC0008385, awarded by the Department of Energy. The Government has certain rights in this invention.