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METHODS AND SYSTEMS FOR ENGINEERING BACTERIAL SYSTEMS TO SHIELD TOXICITY DURING NON-NATIVE PROTEIN EXPRESSION AND PURIFICATION

United States Patent Application

20160362697
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Livermore National Laboratory - Visit the Industrial Partnerships Office Website
The invention described herein relates to methods, systems, compositions and cells to provide one or more toxic non-native proteins in a cell, wherein the one or more toxic non-native proteins are contained in at least one empty microcompartment within the cell.
YUNG, Mimi Cho (MILPITAS, CA), BOURGUET, Feliza A. (LIVERMORE, CA), CARPENTER, Timothy S. (LIVERMORE, CA), COLEMAN, Matthew A. (OAKLAND, CA)
15/ 178,454
June 9, 2016
STATEMENT OF GOVERNMENT GRANT [0002] The invention was made with Government support under Contract No. DE-AC52-07NA27344 between the U.S. Department of Energy and Lawrence Livermore National Security, LLC, for the operation of Lawrence Livermore National Security. The Government may have certain rights to the invention.