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TORROIDAL MESOPOROUS SILICA NANOPARTICLES (TMSNPS) AND RELATED PROTOCELLS

United States Patent Application

*** PATENT GRANTED ***
20160338954
9,855,217
A1
View the Complete Application at the US Patent & Trademark Office
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In one aspect, the invention provides novel monodisperse, colloidally-stable, torroidal mesoporous silica nanoparticles (TMSNPs) which are synthesized from ellipsoid-shaped mesoporous silica nanoparticles (MSNPs) which are prepared using an ammonia base-catalyzed method under a low surfactant conditions. Significantly, the TMSNPs can be loaded simultaneously with a small molecule active agent, a siRNA, a mRNA, a plasmid and other cargo and can be used in the diagnosis and/or treatment of a variety of disorders, including a cancer, a bacterial infection and/or a viral infection, among others. Related protocells, pharmaceutical compositions and therapeutic and diagnostic methods are also provided.
Brinker, C. Jeffrey (Albuquerque, NM), Lin, Yu-Shen (Albuquerque, NM)
15/ 023,110
September 18, 2014
STATEMENT REGARDING FEDERAL FUNDING [0002] This invention was made with government support under DE-AC04-94AL85000 awarded by the U.S. Department of Energy and U01 CA15179201 awarded by the National Institutes of Health. The government has certain rights in the invention.