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MANIPULATING THE CIRCADIAN CLOCK TO INCREASE GENE EXPRESSION

United States Patent Application

20160289646
A1
View the Complete Application at the US Patent & Trademark Office
A method of increasing gene expression by manipulating the circadian clock is described that includes transforming a photosynthetic organism to include an expression control sequence that modulates the expression of a clock gene to increase expression of a target gene. Photosynthetic organism having a modified circadian cycle reflecting this method are also described.
JOHNSON, CARL HIRSCHIE (NASHVILLE, TN), WEYMAN, PHILIP D. (CARDIFF, CA), XU, QING (NORTH POTOMAC, MD), XU, YAO (NASHVILLE, TN)
14/ 933,622
November 5, 2015
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH [0002] The present invention was supported by grants from the National Institute of General Medical Sciences (NIGMS R01 GM067152 and R01 GM088595) and the U.S. Department of Energy (DE-FG36-05G015027). The Government has certain rights in this invention.