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AN AUTOMATED, MULTI-POT HIGH-PRESSURE RADIO-SYNTHESIZER FOR PRODUCTION OF PET TRACERS

United States Patent Application

20160280734
A1
View the Complete Application at the US Patent & Trademark Office
An automated radiosynthesizer device includes a plurality of reactor assemblies, each reactor assembly being operatively connected to a horizontal actuator for moving the reactor assembly in the horizontal direction and a vertical actuator for moving the reactor assembly in the vertical direction. A plurality of disposable cassettes are disposed above each of the plurality of reactor assemblies, each cassette comprising a lower surface comprising a plurality of sealed and un-sealed gaskets, wherein the un-sealed gaskets are connected to internal fluid paths within the cassette. The device includes a three-axis reagent and gas handling robot disposed above the plurality of cassettes and terminates in a vial gripper and a gas manifold having an inert gas port and a vacuum port. The device includes a control system configured to control the horizontal actuator and vertical actuator of each reactor assembly and the three-axis reagent and gas handling robot.
Moore, Melissa (Los Angeles, CA), Van Dam, R. Michael (Los Angeles, CA), Quinn, Kevin (Irvine, CA), Claggett, Shane (Los Angeles, CA), Herman, Henry (Los Angeles, CA), Lazari, Mark (North Hills, CA)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
14/ 777,973
March 26, 2014
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] This invention was made with Government support under DE-FG02-06ER64249 and DE-SC0001249, awarded by the Department of Energy. The Government has certain rights in the invention.