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Methods compositions and kits for imaging cells and tissues using nanoparticles and spatial frequency heterodyne imaging

United States Patent Application

20160274086
A1
View the Complete Application at the US Patent & Trademark Office
Methods, compositions, systems, devices and kits are provided herein for preparing and using a nanoparticle composition and spatial frequency heterodyne imaging for visualizing cells or tissues. In various embodiments, the nanoparticle composition includes at least one of: a nanoparticle, a polymer layer, and a binding agent, such that the polymer layer coats the nanoparticle and is for example a polyethylene glycol, a polyelectrolyte, an anionic polymer, or a cationic polymer, and such that the binding agent that specifically binds the cells or the tissue. Methods, compositions, systems, devices and kits are provided for identifying potential therapeutic agents in a model using the nanoparticle composition and spatial frequency heterodyne imaging.
Rose-Petruck, Christoph (Barrington, RI), Wands, Jack R. (East Greenwich, RI), Rand, Danielle (Quincy, MA), Derdak, Zoltan (Riverside, RI), Ortiz, Vivian (Nashville, TN)
Brown University (Providence RI), Rhode Island Hospital (Providence RI)
15/ 088,574
April 1, 2016
GOVERNMENT FUNDING [0002] A portion of this work was supported by U.S. Department of Energy grant DE-FG02-08ER15937, U.S. Department of Education GAANN award P200A090076, and the National Institutes of Health grant CA123544. The government has certain rights in this invention.