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Recombinant Cells and Organisms Having Persistent Nonstandard Amino Acid Dependence and Methods of Making Them

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Novel recombinant cells and recombinant organisms persistently expressing nonstandard amino acids (NSAAs) are provided. Methods of making novel recombinant cells and recombinant organisms dependent on persistently expressing NSAAs for survival are also provided. These methods may be used to make safe recombinant cells and recombinant organisms and/or to provide a selective pressure to maintain one or more reassigned codon functions in recombinant cells and recombinant organisms.
Church, George M. (Brookline, MA), Mandell, Daniel J. (Brookline, MA), Lajoie, Marc J. (Cambridge, MA)
15/ 025,406
September 26, 2014
STATEMENT OF GOVERNMENT INTERESTS [0002] This invention was made with government support under Department of Energy grant number DE-FG02-02ER63445, National Science Foundation grant number SA5283-11210, and Defense Advanced Research Projects Agency grant number N66001-12-C-4040. The Government has certain rights in the invention.