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Pyrrolysine synthesis and modification

United States Patent Application

20060183888
A1
View the Complete Application at the US Patent & Trademark Office
Synthetic L-pyrrolysine of formula I, and derivatives thereof, chemical methods of preparing these amino acids and derivatives, and methods of derivatizing these amino acids after incorporation into a peptide or protein. ##STR1## Also provided are derivatives and methods of preparing derivatives, including addition of substituents at any substitutable position; modifications to the lysine alkyl chain; modifications of the pyrroline ring. Also provided are methods of adding labels to the pyrrolysine or derivative thereof.
Chan, Michael K. (Hilliard, OH), Krzycki, Joseph A. (Columbus, OH)
11/ 203,820
August 15, 2005
STATEMENT REGARDING FEDERALLY FUNDED RESEARCH [0002] This work was supported at least in part by grants from the National Science Foundation (MCB-9808914); the Department of Energy (DE-FG02-92ER20042); and the National Institutes of Health (GM 061796). The Federal Government may have certain rights in this invention.