The present invention provides for a genetically modified yeast host cell capable of producing one or more fatty acids, or fatty acid-derived compounds, or a mixture thereof, comprising: (a) increased expression of acetyl-CoA carboxylase (such as ACC1), (b) increased expression of one or more fatty acid synthases (such as FAS1 and FAS2), and (c) optionally reduced expression of one or more enzymes involved in or in the .beta.-oxidation pathway (such as peroxisomal transporters PXA1 and PXA2, and .beta.-oxidation enzymes POX1, POX2, and POX3).
STATEMENT OF GOVERNMENTAL SUPPORT
 The invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in the invention.