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Use of compositions that increase glutamate receptor activity in treatment of brain injury

United States Patent Application

20060167099
A1
View the Complete Application at the US Patent & Trademark Office
The present invention provides a method for treating a brain injury. This method comprises administering to a mammal afflicted with a brain injury a pharmaceutical composition therapeutically effective to increase glutamate receptor activity in the brain of said mammal. The pharmaceutical composition is to be administered after an acute postinjury phase of said affliction, a time when the level of NMDA receptor activity in the brain is below normal. The pharmaceutical composition may be administered subsequent to an initial treatment with an NMDA antagonist, the NMDA antagonist being administered during the acute postinjury phase of said affliction, a time when the level of NMDA receptor activity is above normal.
Biegon, Anat (Port Jefferson, NY), Shohami, Esther (Mevaseret-Zion, IL)
10/ 984,556
November 9, 2004
GOVERNMENT SUPPORT [0001] This invention was made in part with government support under Department of Energy Grant KP140102 to A. Biegon. The government has certain rights in the invention.