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GENETICALLY ENCODED SENSORS FOR IMAGING PROTEINS AND THEIR COMPLEXES

United States Patent Application

20160146827
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Isolated truncated and mutated sensor proteins derived from flavoproteins that are 12-20 KDa or less, genetically encoded for detection and imaging of protein complexes having long fluorescent lifetimes that can be 4.0 ns or greater.
Marriott, Gerard (Palo Alto, CA), Hoepker, Alexander Chris (Oakland, CA), Yan, Yuling (Oakland, CA)
14/ 946,461
November 19, 2015
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The present invention was supported by the Laboratory Directed Research and Development program under Contract No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The present invention was supported under RO1 GM086233-02 awarded by the NIH. The government has certain rights to the invention.