Skip to Content
Find More Like This
Return to Search


United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Provided herein are methods and compositions for the electrochemical selective radiofluorination of aromatic molecules. The resulting fluorine-18 labeled compounds are ideal radionuclides for use in Positron Emission Tomography (PET); they are also difficult to radiolabel efficiently and with high specific activity using existing approaches. For example, radiopharmaceuticals such as [F18]L-DOPA, which is indispensable in PET brain disease imaging, may be made electrochemically with high radiochemical yield and high specific activity using 18F-. The invention process described herein opens new possibilities and provides wider access to PET tracers such as 18F-L-Dopa, since 18F- is much more widely available than the 18F.sub.2, currently used for synthesis of electron rich substrates.
Sadeghi, Saman (Los Angeles, CA), He, Qinggang (Los Angeles, CA), Lebedev, Artem (Los Angeles, CA)
14/ 937,649
November 10, 2015
STATEMENT OF GOVERNMENT SUPPORT [0002] This invention was made with Government support awarded by the U.S. Department of Energy. The Government has certain rights in this invention.