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Engineered Microorganisms Having Resistance to Ionic Liquids

United States Patent Application

View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a method of genetically modifying microorganisms to enhance resistance to ionic liquids using a yeast Major Facilitator Superfamily (MFS), or a Salmonella MFS SmvA Pump or SmvR Regulator, a Small Multidrug Resistance Family (SMR), or Saccharomyces cerevisiae YDR090C, polypeptide, host cells genetically modified in accordance with the methods, and methods of using the host cells in a reaction comprising biomass that has been pretreated with ionic liquids.
Thelen, Michael P. (Danville, CA), Higgins, Douglas A. (Point Pleasant, NJ), Ruegg, Thomas L. (Berkeley, CA)
Lawrence Livermore National Security, LLC (Livermore CA)
14/ 717,962
May 20, 2015
STATEMENT OF GOVERNMENTAL SUPPORT [0002] This invention was made with government support under Contract No. DE-AC02-05CH11231 awarded by the United States Department of Energy and Award No. EEC-0540879 awarded by the National Science Foundation. The government has certain rights in the invention.