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United States Patent Application

View the Complete Application at the US Patent & Trademark Office
The present invention provides a conjugate having a peptide with from about 10 to about 100 amino acids, wherein the peptide adopts a helical structure. The conjugate also includes a first polymer covalently linked to the peptide, and a hydrophobic moiety covalently linked to the N-terminus of the peptide, wherein the hydrophobic moiety comprises a second polymer or a lipid moiety. The present invention also provides helix bundles form by self-assembling the conjugates, and particles formed by self-assembling the helix bundles. Methods of preparing the helix bundles and particles are also provided.
Xu, Ting (Berkeley, CA), Dong, He (Potsdam, NY), Shu, Jessica (Apple Valley, MN)
14/ 700,018
April 29, 2015
STATEMENT AS TO RIGHTS TO INVENTIONS MADE UNDER FEDERALLY SPONSORED RESEARCH AND DEVELOPMENT [0002] This invention was made with Government support under Grant No. KC0202010, awarded by the Department of Energy-BES. The Government has certain rights in this invention.