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ENZYMES FOR PRODUCING NON-STRAIGHT-CHAIN FATTY ACIDS

United States Patent Application

20150376659
A1
View the Complete Application at the US Patent & Trademark Office
Enzymes for producing non-straight-chain fatty acids, microorganisms comprising the enzymes, and in vivo and in vitro uses of the enzymes. Provided are enzymes capable of producing various non-straight-chain fatty acids, including branched-chain fatty acids, cyclic fatty acids, and furan-containing fatty acids. The enzymes include RSP2144, RSP1091, and RSP1090 from Rhodobacter sphaeroides and homologs thereof. The enzymes can be purified to produce non-straight-chain fatty acids in vitro or expressed in microorganisms to produce non-straight-chain fatty acids in vivo. The microorganisms can be fine-tuned to produce a specific type of non-straight-chain fatty acid by expressing, overexpressing, or deleting the enzymes in various combinations.
Lemke, Rachelle A.S. (Madison, WI), Donohue, Timothy James (Middleton, WI), Coon, Joshua J. (Middleton, WI), Peterson, Amelia C. (Bremen, DE), Westphall, Michael S. (Fitchburg, WI)
WISCONSIN ALUMNI RESEARCH FOUNDATION (Madison WI)
14/ 755,213
June 30, 2015
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH [0001] This invention was made with government support under DE-FC02-07ER64494 awarded by the US Department of Energy and GM107199 and GM075273 awarded by the National Institutes of Health. The government has certain rights in the invention.