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Synthetic Transcription Factor and Uses Thereof

United States Patent Application

20150353614
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a synthetic transcription factor (TF) comprising a first peptide capable of binding a target ligand, a second peptide capable of binding a target DNA, and a peptide linker linking the first and second peptides. The present invention also provide for a system for modulating the mutagenesis frequency of a host cell. The host cell has a mutator rate (R) which is inversely proportional to a phenotypic trait (P).
Chou, Howard H. (Berkeley, CA), Keasling, Jay D. (Berkeley, CA), Zotchev, Sergey (Trondheim, NO)
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (Oakland CA)
14/ 735,985
June 10, 2015
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The invention described and claimed herein was made utilizing funds supplied by the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The government has certain rights in this invention.