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NITROGEN-RICH MACROCYCLIC LIGANDS, CHELATION COMPLEXES THEREOF, AND PROCESS FOR SELECTIVE CHELATION OF RADIOACTIVE BISMUTH IONS WITH THE LIGANDS

United States Patent Application

20150344508
A1
View the Complete Application at the US Patent & Trademark Office
Los Alamos National Laboratory - Visit the Technology Transfer Division Website
Selective chelation of bismuth radionuclide ions from a mixture including actinium radionuclide ions involves exposing a ligand to an aqueous solution that includes bismuth radionuclide ions and actinium radionuclide ions under conditions whereby the bismuth radionuclide ions selectively chelate to the ligand for form cationic complexes of the bismuth radionuclide ions. and separating the cationic complexes of the bismuth radionuclide ions from the actinium radionuclide ions. The ligands have a structure based on a 12-membered cyclen ring and may include pendant functional groups that can be derivatized with biological targeting vectors for targeted alpha therapy.
Wilson, Justin (Los Alamos, NM), Birnbaum, Eva (Los Alamos, NM), John, Kevin (Santa Fe, NM), Nortier, Francois (Los Alamos, NM), Fassbender, Michael (Los Alamos, NM), Radchenko, Valery (Los Alamos, NM), Engle, Jonathan Ward (Los Alamos, NM)
Los Alamos National Security, LLC (Los Alamos NM)
14/ 703,253
May 4, 2015
STATEMENT REGARDING FEDERAL RIGHTS [0002] This invention was made with government support under Contract No. DE-AC52-06NA25396 awarded by the U.S. Department of Energy. The government has certain rights in the invention.