Skip to Content
Find More Like This
Return to Search

NUCLEIC ACIDS USEFUL FOR INTEGRATING INTO AND GENE EXPRESSION IN HYPERTHERMOPHILIC ACIDOPHILIC ARCHAEA

United States Patent Application

20150291948
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
The present invention provides for a novel recombinant or isolated nucleic acid useful for integrating or being maintained in an Archaea or acidophilic hyperthermophilic eubacteria. The nucleic acid encodes a nucleotide sequence that is capable of stably integrating into the chromosome of a host cell, or being maintained as an extrachromosomal element in a host cell, that is an Archea, and a nucleotide sequence of interest. The present invention also provides for an Archaea host cell comprising the nucleic acid stably integrated into the chromosome or maintained episomally in the host cell, and a method of expressing the nucleotide sequence of interest in the host cell and/or directing glycosylation, multimerization, and/or membrane association or integration.
Yannone, Steven M. (Concord, CA), Barnebey, Adam (Berkeley, CA)
14/ 646,673
November 21, 2013
STATEMENT OF GOVERNMENTAL SUPPORT [0002] The invention described and claimed herein was made utilizing funds supplied by the U.S. Department of Energy under Contract No. DE-AC02-05CH11231. The government has certain rights in this invention.