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BIOACTIVE COMPOSITIONS FOR HIGH AVIDITY CELL CAPTURE

United States Patent Application

20150259668
A1
View the Complete Application at the US Patent & Trademark Office
Oak Ridge National Laboratory - Visit the Partnerships Directorate Website
A composition useful for cell capture, the composition comprising a solid substrate on which is affixed a patterned polymer, and a cell-targeting agent attached to said patterned polymer, wherein said cell-targeting agent is exposed. Also described is a method for the preparation of the cell capturing composition, as well as flow through devices in which the cell capturing composition is incorporated. Further described is a method of capturing cells by contacting the cell-capturing composition with a liquid or gaseous sample containing cells. The method for capturing cells may also be a method for testing for the presence of one or more classes or species of cells or cellular organisms in a liquid or gaseous sample.
Hansen, Ryan Robert (Knoxville, TN), Retterer, Scott T. (Knoxville, TN), Lokitz, Bradley Steward (Knoxville, TN), Morrell-Falvey, Jennifer L. (Knoxville, TN), Salazar, Juan Pablo Hinestrosa (San Diego, CA), Messman, Jamie Michael (Leawood, KS), Kilbey, II, Sidney Michael (Knoxville, TN), Ankner, John Francis (Oak Ridge, TN)
14/ 215,552
March 17, 2014
[0001] This invention was made with government support under Prime Contract No. DE-AC05-000R22725 awarded by the U.S. Department of Energy. The government has certain rights in the invention.