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Neisseria meningitidis serogroup a capsular polysaccharide acetyltransferase, methods and compositions

United States Patent Application

20060073168
A1
View the Complete Application at the US Patent & Trademark Office
Provided are recombinant DNA molecules that do not occur in nature encoding an O-acetyltransferase, vectors that direct expression of an O-acetyltransferase, recombinant host cells which express an O-acetyltransferase, methods for recombinant production of an O-acetyltransferase, methods for acetylating capsular polysaccharides, especially those of a Serogroup A Neisseria meningitidis using a recombinant O-acetyltransferase, and immunogenic compositions comprising the acetylated capsular polysaccharide.
Stephens, David S. (Stone Mountain, GA), Gudlavalleti, Seshu K. (Atlanta, GA), Tzeng, Yih-Ling (Atlanta, GA), Datta, Anup K. (La Jolla, CA), Carlson, Russell W. (Athens, GA)
11/ 201,774
August 11, 2005
ACKNOWLEDGMENT OF FEDERAL RESEARCH SUPPORT [0002] This invention was made, at least in part, with funding from the National Institutes of Health (Grant No. AI40247) and the Department of Energy (Grant No. DE-FG02-93ER20097). Accordingly, the United States Government has certain rights in this invention.