Synthetic-aperture ultrasound tomography systems and methods using scanning arrays and algorithms configured to simultaneously acquire ultrasound transmission and reflection data, and process the data for improved ultrasound tomography imaging, wherein the tomography imaging comprises total-variation regularization, or a modified total variation regularization, particularly with edge-guided or spatially variant regularization.
INCORPORATION-BY-REFERENCE OF COMPUTER PROGRAM APPENDIX
 This invention was made with Government support under Contract No. DE-AC52-06NA25396 awarded by the Department of Energy, and Grant No. MIPR0LDATM0144 from the Breast Cancer Research Program of DoD-Congressionally Directed Medical Research Programs. The Government has certain rights in the invention.