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MICROREACTOR AND METHOD FOR PREPARING A RADIOLABELED COMPLEX OR A BIOMOLECULE CONJUGATE

United States Patent Application

20150151268
A1
View the Complete Application at the US Patent & Trademark Office
A microreactor for preparing a radiolabeled complex or a biomolecule conjugate comprises a microchannel for fluid flow, where the microchannel comprises a mixing portion comprising one or more passive mixing elements, and a reservoir for incubating a mixed fluid. The reservoir is in fluid communication with the microchannel and is disposed downstream of the mixing portion. A method of preparing a radiolabeled complex includes flowing a radiometal solution comprising a metallic radionuclide through a downstream mixing portion of a microchannel, where the downstream mixing portion includes one or more passive mixing elements, and flowing a ligand solution comprising a bifunctional chelator through the downstream mixing portion. The ligand solution and the radiometal solution are passively mixed while in the downstream mixing portion to initiate a chelation reaction between the metallic radionuclide and the bifunctional chelator. The chelation reaction is completed to form a radiolabeled complex.
Reichert, David E. (St. Louis, MO), Kenis, Paul J.A. (Champaign, IL), Wheeler, Tobias D. (Alameda, CA), Desai, Amit V. (Urbana, IL), Zeng, Dexing (Pittsburgh, PA), Onal, Birce C. (Champaign, IL)
The Board of Trustees of the University of Illinois (Urbana IL), Washington University (St. Louis MO)
14/ 613,778
February 4, 2015
FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] This invention was made with government support under grant number DE-FG02-08ER64682 from the Department of Energy Office of Biological and Environmental Research and under grant number R24 CA86307 from the National Institutes of Health. The government has certain rights in this invention.