The present disclosure provides nucleic acids encoding an RNA recognition sequence positioned proximal to an insertion site for the insertion of a sequence of interest; and host cells genetically modified with the nucleic acids. The present disclosure also provides methods of modifying the activity of a target RNA, and kits and compositions for carrying out the methods.
STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH
 This invention was made with government support under Grant Nos. EEC-0540879 and MCB-0950971 awarded by the National Science Foundation, and Grant No. DE-AC02-05CH11231 awarded by the U.S. Department of Energy. The government has certain rights in the invention.