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DEVICES AND METHODS FOR DETERMINING SENSITIVITY TO RADIATION

United States Patent Application

20150017092
A1
View the Complete Application at the US Patent & Trademark Office
Lawrence Berkeley National Laboratory - Visit the Technology Transfer and Intellectual Property Management Department Website
Systems and methods for determining the sensitivity of cells (and/or a subject) to ionizing radiation are provided. The systems can comprise a microfluidic device comprising a plurality of microfluidic cavities each configured to contain cells; a source of ionizing radiation configured to deliver ionizing radiation to cells in the microfluidic cavities; and an imaging system configured to detect radiation-induced foci in cells when they are disposed in the microfluidic cavities. The methods can involve contacting a biological sample comprising cells from a subject with ionizing radiation; detecting and quantifying radiation induced foci in the cells at least two different time points; and determining a repair kinetic for radiation induced foci that is a measure of the rate of disappearance of the foci. Methodologies are also provided for in-home blood collection and fixation of nucleated blood cells in a manner to preserve health and fitness biomarkers inherent to these cells.
Costes, Sylvain V. (Albany, CA), Gomez-Sjoberg, Rafael (Menlo Park, CA), Yannone, Steven M. (Concord, CA)
14/ 378,617
March 14, 2013
STATEMENT OF GOVERNMENTAL SUPPORT [0002] This work was supported in part by Grant No DE-AC02-05CH11231 from the Department of Energy (DOE). The Government has certain rights in this invention.