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RATIONAL ASSEMBLY OF NANOPARTICLE SUPERLATTICES WITH DESIGNED LATTICE SYMMETRIES

United States Patent Application

20150017444
A1
View the Complete Application at the US Patent & Trademark Office
Brookhaven National Laboratory - Visit the Office of Technology Commercialization and Partnerships Website
A method for lattice design via multivalent linkers (LDML) is disclosed that introduces a rationally designed symmetry of connections between particles in order to achieve control over the morphology of their assembly. The method affords the inclusion of different programmable interactions within one linker that allow an assembly of different types of particles. The designed symmetry of connections is preferably provided utilizing DNA encoding. The linkers may include fabricated "patchy" particles, DNA scaffold constructs and Y-shaped DNA linkers, anisotropic particles, which are preferably functionalized with DNA, multimeric protein-DNA complexes, and particles with finite numbers of DNA linkers.
Gang, Oleg (New York, NY), Lu, Fang (Middle Island, NY), Tagawa, Miho (Upton, NY)
14/ 373,161
January 18, 2013
STATEMENT OF GOVERNMENT RIGHTS [0002] This invention was made with Government support under contract number DE-AC02-98CH10886, awarded by the U.S. Department of Energy. The Government has certain rights in the invention.